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OSTEOLYTIC LESION SECONDARY TO METASTATIC RENAL CELL CARCINOMA IN GRUEN ZONE 2 FOLLOWING TOTAL HIP REPLACEMENT-A CASE REPORT

Bassetlaw District general Hospital, Worksop, Nottinghamshire.

We present a case of osteolytic lesion in Gruen Zone 2, 3 in a six-month post-operative cemented THR initially diagnosed as early loosening-?Septic. Investigations and biopsy revealed metastatic renal cell carcinoma.

A 79 year old gentleman had a Left cemented THR and was symptom free post-operative. Six months later he had pain in the left groin and thigh. Examination revealed painless hip movements. X-ray showed lytic area in zone 2 and 3. ESR -90 mm and CRP – 50 mg/dl. Hip aspiration excluded sepsis. Bone scan showed increased uptake of left femoral shaft, right scapula and L1 vertebra. Bone chemistry, renal & liver Assay and tumour markers were normal.

Open biopsy showed erosion of lateral cortex, with friable soft tissue mass with profuse bleeding. Histopathological report showed classical clear cell renal cell carcinoma. CT abdomen and chest revealed multiple nodules in lung fields, multiple nodules in liver, mass in both kidneys consistent with Renal cell carcinoma, multiple skeletal lytic lesions.

Patient was referred to oncologist for palliative treatment

DISCUSSION: In case of osteolytic erosive lesions at cement bone interface, the possibility of metastatic lesions should be considered.

In old age groups Biopsy is recommended to exclude malignancy after exclusion of septic and aseptic loosening and abdominal ultrasound to exclude primaries.

Correspondence should be addressed to Mr Bimal Singh, c/o BOSA at the Royal College of Surgeons, 35–43 Lincoln’s Inn Fields, London WC2A 3PE